Director/Senior Director, National Accounts - Central

About this role

About Stoke:

Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/

Position Purpose:

Stoke Therapeutics is seeking a Director/Senior Director, National Accounts, to join our Market Access organization at a pivotal moment in the company’s history. This individual will serve as the primary relationship owner for all accounts in their region.

The Director/Senior Director, National Accounts will lead and execute Stoke’s payer access strategy from the ground up. This individual will engage targeted accounts and gain meaningful access to all levels of policy decision-makers to advance coverage timelines. The successful candidate will establish Stoke’s credibility and share key clinical data with medical benefit policy decision makers to ensure there is no gap between FDA approval and patient access.

This role is built for a commercially astute market access professional who has navigated - rare or specialty product launches and is motivated by the opportunity to build something consequential—for a medicine, and for the patients who have been waiting for it. The candidate will have the ability to operate nimbly within Stoke’s growing commercial organization while partnering closely with our medical, commercial, government affairs, and patient advocacy colleagues.

Key Responsibilities:

Account Strategy & Launch Readiness

• Develop and execute pre-launch and launch-phase access strategies, establishing Stoke’s presence with key accounts.

• Serve as strategic leader for key accounts in the region

• Develop account-specific action plans that shorten the timeline from FDA approval to an active, positive coverage determination.

• Build payer relationships and establish Stoke’s credibility with medical benefit policy decision-makers before NDA submission, ensuring seamless coverage between approval and patient access.

• Develop multi-year access plans that anticipate commercial cycles and competitive coverage shifts, balancing account-level execution with a national access strategy.

Payer Engagement & Coverage

• Educate payers on clinical evidence, FDA labeling, treatment guidelines, and health-economic data to support coverage decisions and eliminate utilization management barriers (step edits, PA criteria, NDC blocks).

• Monitor medical policy language at each account and partner with Medical Affairs, HEOR, and Advocacy to respond to and proactively shape policy criteria.

• Proactively engage payer Medical Directors to obtain informal guidance letters or billing instructions that bridge the gap between launch and permanent J code assignment.

• Engage and influence policy decision-makers for a medical benefit product to achieve desired coverage policy outcomes.

Reimbursement & J Code Management

• Serve as the company’s subject-matter expert on buy-and-bill reimbursement dynamics for products carrying a miscellaneous J code (J3490/J3590) pending assignment of a permanent, product-specific J code.

• Educate payer medical policy teams on correct claims submission procedures, billing unit conventions, and NDC-to-J code crosswalk requirements to minimize claim denials during the unclassified code period.

Cross-Functional Collaboration

• Drive alignment across Stoke’s commercial team and field medical team without direct reporting relationships, building internal coalitions across Medical, HEOR, Reimbursement, Government Affairs, Legal, Trade &